What's so great about working with really funny women is that vanity comes second. Whatever makes it real and funny they're going to go for and it's just great.
I love funny people and when I'm with funny people or people who are amusing in their weirdness I love it. Because that to me is funny as opposed to someone who stops and says 'Hey let me tell you a joke.'
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What I don't like is when I see stuff that I know has had a lot of improv done or is playing around where there's no purpose to the scene other than to just be funny. What you don't want is funny scene funny scene funny scene and now here's the epiphany scene and then the movie's over.