Those of us who were brought up as Christians and have lost our faith have retained the sense of sin without the saving belief in redemption. This poisons our thought and so paralyses us in action.
If faith is lost there is no security and there is no life for him who does not adhere to religion.
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My gut feeling about sequels is that they should be premeditated: You should try to write a trilogy first or at least sketch out a trilogy if you have any faith in your film.