Sigmund Freud was the apostle of disbelief. He was the one who made psychoanalysis a part of our culture and in so doing he kicked out a flying buttress that had been essential for holding up our cathedral of faith.
If faith is lost there is no security and there is no life for him who does not adhere to religion.
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My gut feeling about sequels is that they should be premeditated: You should try to write a trilogy first or at least sketch out a trilogy if you have any faith in your film.