I think it's realistic to have hope. One can be a perverse idealist and say the easiest thing: 'I despair. The world's no good.' That's a perverse idealist. It's practical to hope because the hope is for us to survive as a human species. That's very realistic.
What can you do if a part of it is uphill? You can't work out another route. You've just got to run the one they give you. But they tell me London is a nice course. Even the cobbles I hope are not very much of a problem for me.
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Now science has presented us with a hope called stem cell research which may provide our scientists with many answers that have for so long been beyond our grasp.