I think any spiritual experience that's worthwhile is not about ego and it will humble you in some way. And also a Zen monk once said to me 'If you're not laughing then you're not getting it.'
If you sit in a position where decisions that you take would have a serious effect on people you can't ignore a lot of experience around the world which says this drug has these negative effects.
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The position that I take partly as a result of living in Asia is where you stop living according to your expectations and you become available to experience things as they are.