Protein engineering is a technology of molecular machines – of molecular machines that are part of replicators – and so it comes from an area that already raises some of the issues that nanotechnology will raise.
It's hard to say exactly what it is about face-to-face contact that makes deals happen but whatever it is it hasn't yet been duplicated by technology.
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We are just fanatics about using the technology to make it all wonderful. We laughed at the fact that we were having such a great time working this way.