The new industries are brainy industries and so-called knowledge workers tend to like to be near other people who are the same. Think of the City of Hollywood. People cluster. This means you have winning regions such as London and Cambridge and losing regions. The people who want to be top lawyers in Sunderland are hoovered up by London.
Medical knowledge and technical savvy are biodegradable. The sort of medicine that was practiced in Boston or New York or Atlanta fifty years ago would be as strange to a medical student or intern today as the ceremonial dance of a !Kung San tribe would seem to a rock festival audience in Hackensack.
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A screen actor is compensated in the knowledge that millions will see his performance at one time where only hundreds will see it on the stage.