We've taken on the major health problems of the poorest – tuberculosis maternal mortality AIDS malaria – in four countries. We've scored some victories in the sense that we've cured or treated thousands and changed the discourse about what is possible.
But if you're asking my opinion I would argue that a social justice approach should be central to medicine and utilized to be central to public health. This could be very simple: the well should take care of the sick.
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The biggest public health challenge is rebuilding health systems. In other words if you look at cholera or maternal mortality or tuberculosis in Haiti they're major problems in Haiti but the biggest problem is rebuilding systems.