I wouldn't totally rule out doing Letterman or the Tonight Show if I had a set that I just happened to write that I thought was funny but was still appropriate for network censors. But I'm not going to go out of my way.
I had seen movies before that that had made me laugh but I had never seen anything even remotely close to as funny as Richard Pryor was just standing there talking.
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The audience changes every night. You're the same person. You have to speak your mind and do the stuff that you think is funny and makes you laugh.