We give a lot of others significance in our lives even when they don't deserve it. It doesn't matter if they're family or if you've known them forever. If they're not good for you they've got to go.
I don't have to look up my family tree because I know that I'm the sap.
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If you have issues with family friends and people at work try and solve these issues head on so you can move on and concentrate on having the life you want.